Next Article in Journal
Vimentin Intermediate Filaments as Potential Target for Cancer Treatment
Previous Article in Journal
Predictors of Response and Survival in Immune Checkpoint Inhibitor-Treated Unresectable Hepatocellular Carcinoma
Previous Article in Special Issue
PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes—Implications for UV-Induced DNA Repair and Photocarcinogenesis
Open AccessReview

PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation

Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt 83, H-6722 Szeged, Hungary
Author to whom correspondence should be addressed.
Cancers 2020, 12(1), 183;
Received: 5 December 2019 / Revised: 19 December 2019 / Accepted: 9 January 2020 / Published: 11 January 2020
(This article belongs to the Special Issue PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer)
Transcription is a multistep, tightly regulated process. During transcription initiation, promoter recognition and pre-initiation complex (PIC) formation take place, in which dynamic recruitment or exchange of transcription activators occur. The precise coordination of the recruitment and removal of transcription factors, as well as chromatin structural changes, are mediated by post-translational modifications (PTMs). Poly(ADP-ribose) polymerases (PARPs) are key players in this process, since they can modulate DNA-binding activities of specific transcription factors through poly-ADP-ribosylation (PARylation). PARylation can regulate the transcription at three different levels: (1) by directly affecting the recruitment of specific transcription factors, (2) by triggering chromatin structural changes during initiation and as a response to cellular stresses, or (3) by post-transcriptionally modulating the stability and degradation of specific mRNAs. In this review, we principally focus on these steps and summarise the recent findings, demonstrating the mechanisms through which PARylation plays a potential regulatory role during transcription and DNA repair. View Full-Text
Keywords: transcription; PARylation; PARP; DNA damage; transcription silencing transcription; PARylation; PARP; DNA damage; transcription silencing
Show Figures

Figure 1

MDPI and ACS Style

Páhi, Z.G.; Borsos, B.N.; Pantazi, V.; Ujfaludi, Z.; Pankotai, T. PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation. Cancers 2020, 12, 183.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop