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Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma

1
Brain Regionalization and Development Gene Unit at Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain
2
Instituto de Neurociencias UMH-CSIC, CIBERSAM of ISCIII, 03550 San Juan de Alicante, Spain
3
Internal Medicine Department at University of Murcia-Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(1), 102; https://doi.org/10.3390/cancers12010102
Received: 26 November 2019 / Revised: 23 December 2019 / Accepted: 27 December 2019 / Published: 31 December 2019
(This article belongs to the Special Issue Tumors of the Central Nervous System: An Update)
Glioblastoma (GB) has been shown to up-regulate autophagy with anti- or pro-oncogenic effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone-mediated autophagy (CMA) in pericytes of peritumoral areas to modulate their immune function through cell-cell interaction and in the tumor’s own benefit. Thus, to understand GB progression, the effect that GB cells could have on autophagy of immune cells that surround the tumor needs to be deeply explored. In this review, we summarize all the latest evidence of several molecular and cellular immunosuppressive mechanisms in the perivascular tumor microenvironment. This immunosuppression has been reported to facilitate GB progression and may be differently modulated by several types of autophagy as a critical point to be considered for therapeutic interventions. View Full-Text
Keywords: autophagy; chaperone-mediated autophagy; tumor; glioblastoma; perivascular cells; pericytes; immunosuppressive; tumor immune tolerance; autophagy inhibitors autophagy; chaperone-mediated autophagy; tumor; glioblastoma; perivascular cells; pericytes; immunosuppressive; tumor immune tolerance; autophagy inhibitors
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MDPI and ACS Style

Molina, M.L.; García-Bernal, D.; Martinez, S.; Valdor, R. Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma. Cancers 2020, 12, 102.

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