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Open AccessFeature PaperReview

The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer

1
Institute for Translational Medicine, Medical College of Qingdao University, Dengzhou Road 38, Qingdao 266021, China
2
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(9), 1313; https://doi.org/10.3390/cancers11091313
Received: 20 July 2019 / Revised: 26 August 2019 / Accepted: 26 August 2019 / Published: 5 September 2019
(This article belongs to the Special Issue Cell Death in Cancer)
Cancer is a category of diseases involving abnormal cell growth with the potential to invade other parts of the body. Chemotherapy is the most widely used first-line treatment for multiple forms of cancer. Chemotherapeutic agents act via targeting the cellular apoptotic pathway. However, cancer cells usually acquire chemoresistance, leading to poor outcomes in cancer patients. For that reason, it is imperative to discover other cell death pathways for improved cancer intervention. Pyroptosis is a new form of programmed cell death that commonly occurs upon pathogen invasion. Pyroptosis is marked by cell swelling and plasma membrane rupture, which results in the release of cytosolic contents into the extracellular space. Currently, pyroptosis is proposed to be an alternative mode of cell death in cancer treatment. Accumulating evidence shows that the key components of pyroptotic cell death pathways, including inflammasomes, gasdermins and pro-inflammatory cytokines, are involved in the initiation and progression of cancer. Interfering with pyroptotic cell death pathways may represent a promising therapeutic option for cancer management. In this review, we describe the current knowledge regarding the biological significance of pyroptotic cell death pathways in cancer pathogenesis and also discuss their potential therapeutic utility. View Full-Text
Keywords: pyroptosis; cancer; inflammasome; gasdermin; pro-inflammatory cytokine; cancer pathogenesis; therapeutic utility pyroptosis; cancer; inflammasome; gasdermin; pro-inflammatory cytokine; cancer pathogenesis; therapeutic utility
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MDPI and ACS Style

Wang, M.; Jiang, S.; Zhang, Y.; Li, P.; Wang, K. The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer. Cancers 2019, 11, 1313.

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