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Open AccessReview

Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy

by 1,†, 1,†, 1, 1,2 and 1,2,*
1
Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, China
2
Key Laboratory of Tumor Pathogenesis and Molecular Pathology, School of Medicine, Nanchang University, Nanchang 330006, China
*
Author to whom correspondence should be addressed.
Both authors equally contributed to this review.
Cancers 2019, 11(9), 1314; https://doi.org/10.3390/cancers11091314
Received: 9 July 2019 / Revised: 27 August 2019 / Accepted: 2 September 2019 / Published: 6 September 2019
(This article belongs to the Special Issue New Insights into Cancer Vaccines and Immunotherapy)
Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene laherparepvec (T-VEC). Despite the approval of these two vaccines, most vaccines have been terminated at the clinical trial stage, which indicates that although they are effective in theory, concerns still exist, including low antigenicity of targeting antigens and tumor heterogeneity. In recent years, with new understanding of the biological function and vaccine potential of outer membrane vesicles (OMVs), their potential application in cancer vaccine design deserves our attention. Therefore, this review focuses on the mechanisms, advantages, and prospects of OMVs as antigen-carrier vaccines in cancer vaccine development. We believe that OMV-based vaccines present a safe and effective cancer therapeutic option with broad application prospects. View Full-Text
Keywords: cancer vaccines; outer membrane vesicles; antigen carrier; therapy cancer vaccines; outer membrane vesicles; antigen carrier; therapy
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MDPI and ACS Style

Zhang, Y.; Fang, Z.; Li, R.; Huang, X.; Liu, Q. Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy. Cancers 2019, 11, 1314.

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