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Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference

1
Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, D2 Dublin, Ireland
2
National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, D9 Dublin, Ireland
3
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute, University College Dublin, Belfield, D4 Dublin, Ireland
4
UCD School of Biology and Environmental Science, University College Dublin, Belfield, D4 Dublin, Ireland
5
UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, D4 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1125; https://doi.org/10.3390/cancers11081125
Received: 25 June 2019 / Revised: 17 July 2019 / Accepted: 6 August 2019 / Published: 7 August 2019
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PDF [271 KB, uploaded 7 August 2019]

Abstract

While conventional cancer treatments, such as surgery, radiotherapy and chemotherapy, have been combined for decades in an effort to treat cancer patients, the emergence of novel fields of cancer research have led to a renewed interest in combining conventional treatments with more innovative approaches. The realisation that cancer progression is not exclusively due to changes in the cancer epithelial cells, but also involves changes in the tumour microenvironment, has opened new avenues for combination treatments. Here we discuss the use of combination therapies presented at the 55th Irish Association for Cancer Research (IACR) Annual Conference, highlighting examples of novel therapeutic strategies which, combined with conventional therapies, may greatly enhance not only the overall outcome for patients, but also the quality of life for cancer survivors. Among the novel treatment strategies, immune metabolism, epigenetic therapies and physical exercise are presented. In addition, novel technologies in the field of precision medicine, which will be useful to discover new therapeutics and to stratify patients for combination treatments, are also discussed. View Full-Text
Keywords: cancer therapeutics; combination therapy; immune therapy; epigenetics; physical exercise; liquid biopsies; multi-omics cancer therapeutics; combination therapy; immune therapy; epigenetics; physical exercise; liquid biopsies; multi-omics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Charmsaz, S.; Collins, D.M.; Perry, A.S.; Prencipe, M. Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference. Cancers 2019, 11, 1125.

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