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The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer

1
Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
2
Department of Thoracic Surgery, Medical University of Graz, 8036 Graz, Austria
3
Research Unit for Non-Coding RNA and Genome Editing, Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
4
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, UTHealth, Texas A&M College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1118; https://doi.org/10.3390/cancers11081118
Received: 25 June 2019 / Revised: 17 July 2019 / Accepted: 2 August 2019 / Published: 6 August 2019
(This article belongs to the Special Issue Inhibitor of Growth (ING) Genes)
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PDF [236 KB, uploaded 6 August 2019]

Abstract

Carcinogenic mutations allow cells to escape governing mechanisms that commonly inhibit uncontrolled cell proliferation and maintain tightly regulated homeostasis between cell death and survival. Members of the inhibition of growth (ING) family act as tumor suppressors, governing cell cycle, apoptosis and cellular senescence. The molecular mechanism of action of ING genes, as well as their anchor points in pathways commonly linked to malignant transformation of cells, have been studied with respect to a variety of cancer specimens. This review of the current literature focuses specifically on the action mode of ING family members in lung cancer. We have summarized data from in vitro and in vivo studies, highlighting the effects of varying levels of ING expression in cancer cells. Based on the increasing insight into the function of these proteins, the use of ING family members as clinically useful biomarkers for lung cancer detection and prognosis will probably become routine in everyday clinical practice. View Full-Text
Keywords: Inhibition of growth; ING; lung cancer; NSCLC Inhibition of growth; ING; lung cancer; NSCLC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Smolle, E.; Fink-Neuboeck, N.; Lindenmann, J.; Smolle-Juettner, F.; Pichler, M. The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer. Cancers 2019, 11, 1118.

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