Next Article in Journal
Liquid Biopsy in Lung Cancer Screening: The Contribution of Metabolomics. Results of A Pilot Study
Next Article in Special Issue
Surgery or Locoregional Approaches for Hepatic Oligometastatic Pancreatic Cancer: Myth, Hope, or Reality?
Previous Article in Journal
EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer
Previous Article in Special Issue
Omics Approaches in Pancreatic Adenocarcinoma
Open AccessArticle

Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer

National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan
Vall d’Hebron University Hospital and Vall d’Hebron Institute of Oncology, 08035 Barcelona, Spain
Groupe Hospitalier Haut-Lévêque, CHU Bordeaux, 33600 Pessac, France
Ipsen Biopharmaceuticals, Inc., Basking Ridge, NJ 07920, USA
Global Medical Affiars, Servier, 8002 Zürich, Switzerland
Ipsen Biopharmaceuticals, Inc., Cambridge, MA 02142, USA
Mayo Clinic Cancer Center, Phoenix, AZ 85054, USA
German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
West German Cancer Center, University Hospital Essen, 45147 Essen, Germany
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1068;
Received: 20 June 2019 / Revised: 23 July 2019 / Accepted: 23 July 2019 / Published: 28 July 2019
(This article belongs to the Special Issue Advances in Pancreatic Cancer Research)
NAPOLI-1 (NCT01494506) was a phase III study of liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy. This post hoc analysis of NAPOLI-1 aimed to develop a predictive nomogram for overall survival (OS) at 6 and 12 months. Analyses were derived from all patients in NAPOLI-1 randomized to receive nal-IRI+5-FU/LV, nal-IRI monotherapy, or 5-FU/LV combination therapy. OS was associated with baseline factors using univariate and multivariable Cox analyses. A predictive nomogram was derived and validated using a concordance index and calibration plots. The univariate analyses identified 21 independent factors that contributed to OS, with eight factors significantly associated with OS. The Karnofsky Performance Score contributed the largest number of points (100), followed by presence of liver metastasis (98) and randomization to nal-IRI+5-FU/LV (96). The other baseline factors showing effects were albumin (g/dL), neutrophil/lymphocyte ratio, carbohydrate antigen 19-9 (U/mL), disease stage at diagnosis, and body mass index (kg/m2). The nomogram was used to predict the 6- and 12-month survival probability. The mean absolute errors between the observed and predicted probabilities for OS at 3, 6, and 9 months were 0.07, 0.08, and 0.07, respectively. This nomogram, based on NAPOLI-1, provides additional insight to aid decision-making for patients with mPDAC after previous gemcitabine-based therapy. View Full-Text
Keywords: liposomal irinotecan; NAPOLI-1; nomogram; pancreatic cancer; survival outcomes liposomal irinotecan; NAPOLI-1; nomogram; pancreatic cancer; survival outcomes
Show Figures

Figure 1

MDPI and ACS Style

Chen, L.-T.; Macarulla, T.; Blanc, J.-F.; Mirakhur, B.; de Jong, F.A.; Belanger, B.; Bekaii-Saab, T.; Siveke, J.T. Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer. Cancers 2019, 11, 1068.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop