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PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics

1
Departments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
2
Departments of Cancer Biology, Pathology, and Urology, Wake Forest University School of Medicine, Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 949; https://doi.org/10.3390/cancers11070949
Received: 13 May 2019 / Revised: 10 June 2019 / Accepted: 30 June 2019 / Published: 5 July 2019
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PDF [3708 KB, uploaded 5 July 2019]
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Abstract

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), as well as the nuclear factor-κ light chain enhancer of activated B cells (NFκB) pathways are highly mutated and/or hyper-activated in a majority of ovarian cancer patients, and are associated with advanced grade and stage disease and poor prognosis. In this review, we will investigate PI3K/AKT/mTOR and their interconnection with NFκB pathway in ovarian cancer cells. View Full-Text
Keywords: PI3K-AKT-mTOR; NFκB; ovarian cancer; therapy PI3K-AKT-mTOR; NFκB; ovarian cancer; therapy
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Ghoneum, A.; Said, N. PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers 2019, 11, 949.

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