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Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges

1
Cellular Oncology group, Biodonostia Health Research Institute, E-20014 San Sebastian, Spain
2
CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), 28029 Madrid, Spain
3
Donostia Universitary Hospital, 20014 San Sebastian, Spain
4
Multiple Sclerosis group, Biodonostia Health Research Institute, 20014 San Sebastian, Spain
5
Spanish Network of Multiple Sclerosis, 08028 Barcelona, Spain
6
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(7), 950; https://doi.org/10.3390/cancers11070950
Received: 15 May 2019 / Revised: 2 July 2019 / Accepted: 4 July 2019 / Published: 5 July 2019
(This article belongs to the Special Issue Liquid Biopsy for Cancer)
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PDF [3352 KB, uploaded 8 July 2019]
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Abstract

Liquid biopsy represents a minimally invasive procedure that can provide similar information from body fluids to what is usually obtained from a tissue biopsy sample. Its implementation in the clinical setting might significantly renew the field of medical oncology, facilitating the introduction of the concepts of precision medicine and patient-tailored therapies. These advances may be useful in the diagnosis of brain tumors that currently require surgery for tissue collection, or to perform genetic tumor profiling for disease classification and guidance of therapy. In this review, we will summarize the most recent advances and putative applications of liquid biopsy in glioblastoma, the most common and malignant adult brain tumor. Moreover, we will discuss the remaining challenges and hurdles in terms of technology and biology for its clinical application. View Full-Text
Keywords: liquid biopsy; glioblastoma; ctDNA liquid biopsy; glioblastoma; ctDNA
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Saenz-Antoñanzas, A.; Auzmendi-Iriarte, J.; Carrasco-Garcia, E.; Moreno-Cugnon, L.; Ruiz, I.; Villanua, J.; Egaña, L.; Otaegui, D.; Samprón, N.; Matheu, A. Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges. Cancers 2019, 11, 950.

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