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Ovarian Cancer Stem Cells: Role in Metastasis and Opportunity for Therapeutic Targeting

Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
Department of Cellular and Integrative Physiology and Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 934;
Received: 6 June 2019 / Revised: 29 June 2019 / Accepted: 30 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Ovarian Cancer Metastasis)
PDF [1471 KB, uploaded 3 July 2019]


Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Cancer stem cells (CSCs) that exist within the bulk tumor survive first-line chemotherapy and contribute to resistant disease with metastasis. Understanding the key features of CSC biology provides valuable opportunities to develop OCSC-directed therapeutics, which will eventually improve the clinical outcomes of patients. Although significant developments have occurred since OCSCs were first described, the involvement of CSCs in ovarian tumor metastasis is not fully understood. Here, we discuss putative CSC markers and the fundamental role of CSCs in facilitating tumor dissemination in OC. Additionally, we focus on promising CSC-targeting strategies in preclinical and clinical studies of OC and discuss potential challenges in CSC research. View Full-Text
Keywords: cancer stem cells; metastasis; ovarian cancer cancer stem cells; metastasis; ovarian cancer

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Zong, X.; Nephew, K.P. Ovarian Cancer Stem Cells: Role in Metastasis and Opportunity for Therapeutic Targeting. Cancers 2019, 11, 934.

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