Next Article in Journal
Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer
Next Article in Special Issue
Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies
Previous Article in Journal
Whole-blood DNA Methylation Markers for Risk Stratification in Colorectal Cancer Screening: A Systematic Review
Previous Article in Special Issue
The Nucleoshuttling of the ATM Protein: A Unified Model to Describe the Individual Response to High- and Low-Dose of Radiation?
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle

Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro

1
Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, v. v. i., Vídeňská 1083, 142 20 Prague 4, Czech Republic
2
Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, v. v. i., Husinec 130, 250 68 Řež, Czech Republic
3
Department of Dosimetry and Application of Ionizing Radiation, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Břehová 7, 115 19 Prague 1, Czech Republic
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 913; https://doi.org/10.3390/cancers11070913
Received: 28 May 2019 / Revised: 21 June 2019 / Accepted: 27 June 2019 / Published: 29 June 2019
  |  
PDF [1787 KB, uploaded 29 June 2019]
  |  

Abstract

Radiotherapy plays a significant role in brain cancer treatment; however, the use of this therapy is often accompanied by neurocognitive decline that is, at least partially, a consequence of radiation-induced damage to neural stem cell populations. Our findings describe features that define the response of neural stem cells (NSCs) to ionizing radiation. We investigated the effects of irradiation on neural stem cells isolated from the ventricular-subventricular zone of mouse brain and cultivated in vitro. Our findings describe the increased transcriptional activity of p53 targets and proliferative arrest after irradiation. Moreover, we show that most cells do not undergo apoptosis after irradiation but rather cease proliferation and start a differentiation program. Induction of differentiation and the demonstrated potential of irradiated cells to differentiate into neurons may represent a mechanism whereby damaged NSCs eliminate potentially hazardous cells and circumvent the debilitating consequences of cumulative DNA damage. View Full-Text
Keywords: neural stem cells; ionizing radiation; proliferation; proliferative arrest; differentiation; apoptosis neural stem cells; ionizing radiation; proliferation; proliferative arrest; differentiation; apoptosis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Konířová, J.; Cupal, L.; Jarošová, Š.; Michaelidesová, A.; Vachelová, J.; Davídková, M.; Bartůněk, P.; Zíková, M. Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro. Cancers 2019, 11, 913.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top