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Open AccessArticle

Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro

1
Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, v. v. i., Vídeňská 1083, 142 20 Prague 4, Czech Republic
2
Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, v. v. i., Husinec 130, 250 68 Řež, Czech Republic
3
Department of Dosimetry and Application of Ionizing Radiation, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Břehová 7, 115 19 Prague 1, Czech Republic
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 913; https://doi.org/10.3390/cancers11070913
Received: 28 May 2019 / Revised: 21 June 2019 / Accepted: 27 June 2019 / Published: 29 June 2019
Radiotherapy plays a significant role in brain cancer treatment; however, the use of this therapy is often accompanied by neurocognitive decline that is, at least partially, a consequence of radiation-induced damage to neural stem cell populations. Our findings describe features that define the response of neural stem cells (NSCs) to ionizing radiation. We investigated the effects of irradiation on neural stem cells isolated from the ventricular-subventricular zone of mouse brain and cultivated in vitro. Our findings describe the increased transcriptional activity of p53 targets and proliferative arrest after irradiation. Moreover, we show that most cells do not undergo apoptosis after irradiation but rather cease proliferation and start a differentiation program. Induction of differentiation and the demonstrated potential of irradiated cells to differentiate into neurons may represent a mechanism whereby damaged NSCs eliminate potentially hazardous cells and circumvent the debilitating consequences of cumulative DNA damage. View Full-Text
Keywords: neural stem cells; ionizing radiation; proliferation; proliferative arrest; differentiation; apoptosis neural stem cells; ionizing radiation; proliferation; proliferative arrest; differentiation; apoptosis
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MDPI and ACS Style

Konířová, J.; Cupal, L.; Jarošová, Š.; Michaelidesová, A.; Vachelová, J.; Davídková, M.; Bartůněk, P.; Zíková, M. Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro. Cancers 2019, 11, 913. https://doi.org/10.3390/cancers11070913

AMA Style

Konířová J, Cupal L, Jarošová Š, Michaelidesová A, Vachelová J, Davídková M, Bartůněk P, Zíková M. Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro. Cancers. 2019; 11(7):913. https://doi.org/10.3390/cancers11070913

Chicago/Turabian Style

Konířová, Jana; Cupal, Lukáš; Jarošová, Šárka; Michaelidesová, Anna; Vachelová, Jana; Davídková, Marie; Bartůněk, Petr; Zíková, Martina. 2019. "Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro" Cancers 11, no. 7: 913. https://doi.org/10.3390/cancers11070913

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