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Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells

by Roberta Peruzzo 1 and Ildiko Szabo 1,2,*
1
Department of Biology, University of Padova, 35131 Padova, Italy
2
CNR Institute of Neuroscience, 35131 Padova, Italy
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(6), 761; https://doi.org/10.3390/cancers11060761
Received: 7 April 2019 / Revised: 16 May 2019 / Accepted: 23 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Cellular Stress in Cancer Progression, Drug Resistance and Treatment)
Mitochondrial ion channels are emerging oncological targets, as modulation of these ion-transporting proteins may impact on mitochondrial membrane potential, efficiency of oxidative phosphorylation and reactive oxygen production. In turn, these factors affect the release of cytochrome c, which is the point of no return during mitochondrial apoptosis. Many of the currently used chemotherapeutics induce programmed cell death causing damage to DNA and subsequent activation of p53-dependent pathways that finally leads to cytochrome c release from the mitochondrial inter-membrane space. The view is emerging, as summarized in the present review, that ion channels located in this organelle may account in several cases for the resistance that cancer cells can develop against classical chemotherapeutics, by preventing drug-induced apoptosis. Thus, pharmacological modulation of these channel activities might be beneficial to fight chemo-resistance of different types of cancer cells. View Full-Text
Keywords: mitochondrial ion channels; permeabilization and cytochrome c release; resistance to apoptosis mitochondrial ion channels; permeabilization and cytochrome c release; resistance to apoptosis
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Peruzzo, R.; Szabo, I. Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells. Cancers 2019, 11, 761.

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