Next Article in Journal
Unleashing Tumour-Dendritic Cells to Fight Cancer by Tackling Their Three A’s: Abundance, Activation and Antigen-Delivery
Previous Article in Journal
Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer
Previous Article in Special Issue
Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells
Article Menu

Export Article

Open AccessReview

Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer

CRBM, CNRS, Univ. Montpellier, “Equipe labellisée Ligue Contre le Cancer”, F-34000 Montpellier, France
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(5), 669; https://doi.org/10.3390/cancers11050669
Received: 24 April 2019 / Revised: 9 May 2019 / Accepted: 12 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Colorectal Cancers)
  |  
PDF [1928 KB, uploaded 14 May 2019]
  |  

Abstract

Tyrosine kinases (TKs) phosphorylate proteins on tyrosine residues as an intracellular signalling mechanism to coordinate intestinal epithelial cell communication and fate decision. Deregulation of their activity is ultimately connected with carcinogenesis. In colorectal cancer (CRC), it is still unclear how aberrant TK activities contribute to tumour formation because TK-encoding genes are not frequently mutated in this cancer. In vertebrates, several TKs are under the control of small adaptor proteins with potential important physiopathological roles. For instance, they can exert tumour suppressor functions in human cancer by targeting several components of the oncogenic TK signalling cascades. Here, we review how the Src-like adaptor protein (SLAP) and the suppressor of cytokine signalling (SOCS) adaptor proteins regulate the SRC and the Janus kinase (JAK) oncogenic pathways, respectively, and how their loss of function in the intestinal epithelium may influence tumour formation. We also discuss the potential therapeutic value of these adaptors in CRC. View Full-Text
Keywords: cell signalling; tyrosine kinase; small adaptor proteins; colorectal cancer; targeted therapy cell signalling; tyrosine kinase; small adaptor proteins; colorectal cancer; targeted therapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Mevizou, R.; Sirvent, A.; Roche, S. Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer. Cancers 2019, 11, 669.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top