Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer
Abstract
:1. Introduction
2. Results
2.1. Gene Expression of KCa and Ca2+ Channels in Normal Mucosa versus CRC Tissues
2.2. Co-Expression of Ca2+ and KCa Channels in CRC
2.3. Gene Expression Analysis According to Tumor Primary Site, Lymph Node Metastases and Tumor Stage
2.4. ORAI3 and TRPC1 Expression Predict Poor Prognosis of CRC Patients
2.5. Upregulated ORAI3/ORAI1 Ratio Predicts Poor Prognosis of CRC Patients
3. Discussion
4. Materials and Methods
4.1. Public Datasets
4.2. Statistical Analysis
4.3. Survival Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variable | Hazard Ratio | 95% CI | Wald’s p-Value |
---|---|---|---|
TCGA (OS n = 602) | |||
ORAI3 (High vs. Low) | 1.72 | (1.21–2.45) | 0.003 |
TRPC1 (High vs. Low) | 1.44 | (1.01–2.06) | 0.042 |
TCGA (EFS n = 602) | |||
ORAI3 (High vs. Low) | 1.6 | (1.2–2.13) | 0.001 |
TRPC1 (High vs. Low) | 1.39 | (1.04–1.85) | 0.025 |
GSE39582 (OS n = 562) | |||
ORAI3 (High vs. Low) | 1.12 | (0.84–1.48) | 0.443 |
TRPC1 (High vs. Low) | 1.18 | (0.89–1.57) | 0.258 |
GSE39582 (RFS n = 557) | |||
ORAI3 (High vs. Low) | 1.43 | (1.06–1.92) | 0.02 |
TRPC1 (High vs. Low) | 1.34 | (1–1.81) | 0.05 |
Variable | Hazard Ratio | 95% CI | Wald’s p-Value |
---|---|---|---|
TCGA (OS n = 602) | |||
ORAI3/1 ratio (High vs. Low) | 1.45 | (1.02–2.07) | 0.037 |
TCGA (EFS n = 602) | |||
ORAI3/1 ratio (High vs. Low) | 1.54 | (1.15–2.06) | 0.003 |
GSE39582 (OS n = 562) | |||
ORAI3/1 ratio (High vs. Low) | 1.47 | (1.1–1.95) | 0.009 |
GSE39582 (RFS n = 557) | |||
ORAI3/1 ratio (High vs. Low) | 1.69 | (1.25–2.28) | 0.001 |
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Ibrahim, S.; Dakik, H.; Vandier, C.; Chautard, R.; Paintaud, G.; Mazurier, F.; Lecomte, T.; Guéguinou, M.; Raoul, W. Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. Cancers 2019, 11, 561. https://doi.org/10.3390/cancers11040561
Ibrahim S, Dakik H, Vandier C, Chautard R, Paintaud G, Mazurier F, Lecomte T, Guéguinou M, Raoul W. Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. Cancers. 2019; 11(4):561. https://doi.org/10.3390/cancers11040561
Chicago/Turabian StyleIbrahim, Sajida, Hassan Dakik, Christophe Vandier, Romain Chautard, Gilles Paintaud, Frédéric Mazurier, Thierry Lecomte, Maxime Guéguinou, and William Raoul. 2019. "Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer" Cancers 11, no. 4: 561. https://doi.org/10.3390/cancers11040561