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Cancers 2019, 11(3), 300; https://doi.org/10.3390/cancers11030300

Association of miR-34a Expression with Quality of Life of Glioblastoma Patients: A Prospective Study

1
Laboratory of Molecular Neurooncology, Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50161 Kaunas, Lithuania
2
Institute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, Tilzes str. 18, LT-47181 Kaunas, Lithuania
3
Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50161 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Received: 4 February 2019 / Revised: 20 February 2019 / Accepted: 26 February 2019 / Published: 4 March 2019
(This article belongs to the Collection Cancer Biomarkers)
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Abstract

MiR-34a acts as tumor-suppressor by targeting many oncogenes related to proliferation, apoptosis, and invasion of gliomas. We studied the relationships between health-related quality of life (HRQOL), depression, and miR-34a expression status in patients with newly diagnosed glioblastoma (GBM). A comprehensive HRQOL assessment was completed by 38 patients with glioblastoma prior to surgical resection and included the European Organization for Research and Treatment of Cancer (EORTC) questionnaire for cancer patients (QLQ-C30) and the Brain Cancer-Specific Quality of Life Questionnaire (QLQ-BN20), the Patient Health Questionnaire-9 (PHQ-9), the Karnofsky performance index (KPS), and The Glasgow Outcome Scale (GOS). The miR-34a expression in glioblastoma tissue was measured using quantitative reverse transcription PCR. Our findings show that lower miR-34a expression is significantly associated with higher tumor volume, worse physical functioning, lower KPS, and greater depressive symptom severity of GBM patients. Moreover, analysis reveals that miR-34a effects might be gender specific, as stronger relationships between miR-34a and patient functioning measures were observed in males when compared to females. Despite the fact that, due to small sample size, our results should be considered as preliminary, our study suggests that miR-34a is associated with tumor burden and can be important for health-related quality of life, functional status, and mood symptoms of glioblastoma patients. View Full-Text
Keywords: glioblastoma; health-related quality of life; miR-34a expression; depression; survival; prognosis glioblastoma; health-related quality of life; miR-34a expression; depression; survival; prognosis
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Vaitkiene, P.; Pranckeviciene, A.; Stakaitis, R.; Steponaitis, G.; Tamasauskas, A.; Bunevicius, A. Association of miR-34a Expression with Quality of Life of Glioblastoma Patients: A Prospective Study. Cancers 2019, 11, 300.

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