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Article

Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes

by
Sungbin Park
1,†,
Heejoo Kim
1,†,
Hwee Won Ji
1,
Hyeon Woo Kim
1,
Sung Hwan Yun
1,
Eun Ha Choi
2 and
Sun Jung Kim
1,*
1
Department of Life Science, Dongguk University-Seoul, Goyang 10326, Korea
2
Plasma Bioscience Research Center, Kwangwoon University, Seoul 01897, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Cancers 2019, 11(12), 2011; https://doi.org/10.3390/cancers11122011
Submission received: 18 October 2019 / Revised: 5 December 2019 / Accepted: 10 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Plasma in Cancer Treatment)
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Abstract

Paclitaxel (Tx) is a widely used therapeutic chemical for breast cancer treatment; however, cancer recurrence remains an obstacle for improved prognosis of cancer patients. In this study, cold atmospheric plasma (CAP) was tested for its potential to overcome the drug resistance. After developing Tx-resistant MCF-7 (MCF-7/TxR) breast cancer cells, CAP was applied to the cells, and its effect on the recovery of drug sensitivity was assessed in both cellular and molecular aspects. Sensitivity to Tx in the MCF-7/TxR cells was restored up to 73% by CAP. A comparison of genome-wide expression profiles between the TxR cells and the CAP-treated cells identified 49 genes that commonly appeared with significant changes. Notably, 20 genes, such as KIF13B, GOLM1, and TLE4, showed opposite expression profiles. The protein expression levels of selected genes, DAGLA and CEACAM1, were recovered to those of their parental cells by CAP. Taken together, CAP inhibited the growth of MCF-7/TxR cancer cells and recovered Tx sensitivity by resetting the expression of multiple drug resistance–related genes. These findings may contribute to extending the application of CAP to the treatment of TxR cancer.
Keywords: apoptosis; cold atmospheric plasma; breast cancer; genome-wide expression; reactive oxygen species apoptosis; cold atmospheric plasma; breast cancer; genome-wide expression; reactive oxygen species

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MDPI and ACS Style

Park, S.; Kim, H.; Ji, H.W.; Kim, H.W.; Yun, S.H.; Choi, E.H.; Kim, S.J. Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes. Cancers 2019, 11, 2011. https://doi.org/10.3390/cancers11122011

AMA Style

Park S, Kim H, Ji HW, Kim HW, Yun SH, Choi EH, Kim SJ. Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes. Cancers. 2019; 11(12):2011. https://doi.org/10.3390/cancers11122011

Chicago/Turabian Style

Park, Sungbin, Heejoo Kim, Hwee Won Ji, Hyeon Woo Kim, Sung Hwan Yun, Eun Ha Choi, and Sun Jung Kim. 2019. "Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes" Cancers 11, no. 12: 2011. https://doi.org/10.3390/cancers11122011

APA Style

Park, S., Kim, H., Ji, H. W., Kim, H. W., Yun, S. H., Choi, E. H., & Kim, S. J. (2019). Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes. Cancers, 11(12), 2011. https://doi.org/10.3390/cancers11122011

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