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Cancers
Volume 11
Issue 12
10.3390/cancers11121949
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Review

The Roles of Sirtuin Family Proteins in Cancer Progression

by
Erhu Zhao
1,2,3,†,
Jianbing Hou
1,2,3,†,
Xiaoxue Ke
1,2,3,
Muhammad Nadeem Abbas
1,2,3,
Saima Kausar
1,2,3,
Lei Zhang
1,2,3 and
Hongjuan Cui
1,2,3,*
1
State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing 400716, China
2
Medical Research Institute, Southwest University, Chongqing 400716, China
3
Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cancers 2019, 11(12), 1949; https://doi.org/10.3390/cancers11121949
Submission received: 11 November 2019 / Revised: 29 November 2019 / Accepted: 2 December 2019 / Published: 5 December 2019
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Abstract

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors.
Keywords: Sirtuins; cell viability; apoptosis; metastasis; tumorigenesis Sirtuins; cell viability; apoptosis; metastasis; tumorigenesis

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MDPI and ACS Style

Zhao, E.; Hou, J.; Ke, X.; Abbas, M.N.; Kausar, S.; Zhang, L.; Cui, H. The Roles of Sirtuin Family Proteins in Cancer Progression. Cancers 2019, 11, 1949. https://doi.org/10.3390/cancers11121949

AMA Style

Zhao E, Hou J, Ke X, Abbas MN, Kausar S, Zhang L, Cui H. The Roles of Sirtuin Family Proteins in Cancer Progression. Cancers. 2019; 11(12):1949. https://doi.org/10.3390/cancers11121949

Chicago/Turabian Style

Zhao, Erhu, Jianbing Hou, Xiaoxue Ke, Muhammad Nadeem Abbas, Saima Kausar, Lei Zhang, and Hongjuan Cui. 2019. "The Roles of Sirtuin Family Proteins in Cancer Progression" Cancers 11, no. 12: 1949. https://doi.org/10.3390/cancers11121949

APA Style

Zhao, E., Hou, J., Ke, X., Abbas, M. N., Kausar, S., Zhang, L., & Cui, H. (2019). The Roles of Sirtuin Family Proteins in Cancer Progression. Cancers, 11(12), 1949. https://doi.org/10.3390/cancers11121949

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