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Article

Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom

1
Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands
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Department of Internal Medicine III, Ludwig-Maximilians University Hospital, 81377 Munich, Germany
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Department of Paediatric Haematology and Oncology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany
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Department of Radiation Oncology, University Hospital Erlangen, 91054 Erlangen, Germany
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Department of Radiation Oncology, University Hospital Tübingen, 72076 Tübingen, Germany
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Department of Radiology, Ludwig-Maximilians University Hospital, 81377 Munich, Germany
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Center for Care and Cure Technologies Eindhoven (C3Te), Department of Electrical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(11), 1709; https://doi.org/10.3390/cancers11111709
Received: 26 September 2019 / Revised: 22 October 2019 / Accepted: 30 October 2019 / Published: 2 November 2019
(This article belongs to the Special Issue Hyperthermia-based Anticancer Treatments)
Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non-invasively measure the 3D-temperature. This study investigates MRT accuracy for MR-hyperthermia hybrid systems located at five European institutions while heating a centric or eccentric target in anthropomorphic phantoms with pelvic and spine structures. Scatter plots, root mean square error (RMSE) and Bland–Altman analysis were used to quantify accuracy of MRT compared to high resistance thermistor probe measurements. For all institutions, a linear relation between MRT and thermistor probes measurements was found with R2 (mean ± standard deviation) of 0.97 ± 0.03 and 0.97 ± 0.02, respectively for centric and eccentric heating targets. The RMSE was found to be 0.52 ± 0.31 °C and 0.30 ± 0.20 °C, respectively. The Bland-Altman evaluation showed a mean difference of 0.46 ± 0.20 °C and 0.13 ± 0.08 °C, respectively. This first multi-institutional evaluation of MR-hyperthermia hybrid systems indicates comparable device performance and good agreement between MRT and thermistor probes measurements. This forms the basis to standardize treatments in multi-institution studies of MR-guided hyperthermia and to elucidate thermal dose-effect relations. View Full-Text
Keywords: quality assurance; radiofrequency hyperthermia; magnetic resonance imaging-guided hyperthermia; magnetic resonance thermometry; thermistor probe; anthropomorphic phantom quality assurance; radiofrequency hyperthermia; magnetic resonance imaging-guided hyperthermia; magnetic resonance thermometry; thermistor probe; anthropomorphic phantom
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MDPI and ACS Style

Curto, S.; Aklan, B.; Mulder, T.; Mils, O.; Schmidt, M.; Lamprecht, U.; Peller, M.; Wessalowski, R.; Lindner, L.H.; Fietkau, R.; Zips, D.; Bellizzi, G.G.; van Holthe, N.; Franckena, M.; Paulides, M.M.; van Rhoon, G.C. Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom. Cancers 2019, 11, 1709. https://doi.org/10.3390/cancers11111709

AMA Style

Curto S, Aklan B, Mulder T, Mils O, Schmidt M, Lamprecht U, Peller M, Wessalowski R, Lindner LH, Fietkau R, Zips D, Bellizzi GG, van Holthe N, Franckena M, Paulides MM, van Rhoon GC. Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom. Cancers. 2019; 11(11):1709. https://doi.org/10.3390/cancers11111709

Chicago/Turabian Style

Curto, Sergio, Bassim Aklan, Tim Mulder, Oliver Mils, Manfred Schmidt, Ulf Lamprecht, Michael Peller, Ruediger Wessalowski, Lars H. Lindner, Rainer Fietkau, Daniel Zips, Gennaro G. Bellizzi, Netteke van Holthe, Martine Franckena, Margarethus M. Paulides, and Gerard C. van Rhoon 2019. "Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom" Cancers 11, no. 11: 1709. https://doi.org/10.3390/cancers11111709

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