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Salivary Gland Function, Antioxidant Defence and Oxidative Damage in the Saliva of Patients with Breast Cancer: Does the BRCA1 Mutation Disturb the Salivary Redox Profile?

1
Department of Prosthodontics, Medical University of Bialystok, Sklodowskiej 24a, 15-276 Bialystok, Poland
2
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland
3
Department of Orthodontics, Medical University of Bialystok, Waszyngtona 15a, 15-274 Bialystok, Poland
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Department of Perinatology, Medical University of Bialystok, Sklodowskiej 24a, 15-276 Bialystok, Poland
5
Department of Restorative Dentistry, Medical University of Bialystok, Sklodowskiej 24a, 15-276 Bialystok, Poland
6
Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15a, 15-274 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1501; https://doi.org/10.3390/cancers11101501
Received: 2 September 2019 / Revised: 30 September 2019 / Accepted: 5 October 2019 / Published: 8 October 2019
: Oxidative stress plays a key role in breast cancer progression. However, little is still known about the relationship between the BRCA1 mutation, the incidence of breast cancer and oral homeostasis. This is the first study to evaluate the secretory function of salivary glands, biomarkers of redox balance, and oxidative damage to proteins and lipids in the saliva of subjects with the BRCA1 mutation. Ninety eight women were enrolled in the study and allocated to four groups based on molecular DNA testing: generally healthy patients without the BRCA1 mutation, patients with breast cancer but without the BRCA1 mutation, generally healthy patients with the BRCA1 mutation, and patients with both breast cancer and the BRCA1 mutation. We demonstrated that saliva from breast cancer patients with the BRCA1 mutation is characterized by enhanced antioxidant capacity and a higher degree of oxidative damage to proteins and lipids. The BRCA1 mutation can cause a predisposition to early salivary gland dysfunction, both in patients with breast cancer and in healthy individuals, leading to a decrease in salivary proteins. Using cluster analysis, we showed that salivary peroxidase, advanced glycation end-products (AGE), total antioxidant status (TAS) and malondialdehyde (MDA) may have particular clinical significance in non-invasive diagnostics of breast cancer. View Full-Text
Keywords: breast cancer; saliva; oxidative stress; redox biomarkers; salivary diagnostics breast cancer; saliva; oxidative stress; redox biomarkers; salivary diagnostics
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Sawczuk, B.; Maciejczyk, M.; Sawczuk-Siemieniuk, M.; Posmyk, R.; Zalewska, A.; Car, H. Salivary Gland Function, Antioxidant Defence and Oxidative Damage in the Saliva of Patients with Breast Cancer: Does the BRCA1 Mutation Disturb the Salivary Redox Profile? Cancers 2019, 11, 1501.

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