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Open AccessArticle

Migration Properties Distinguish Tumor Cells of Classical Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma Cells

1
Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
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Institute of Informatics/Frankfurt Institute for Advanced Studies, Goethe University, 60438 Frankfurt am Main, Germany
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Inserm, U1016, Institut Cochin, CNRS, UMR8104 and Université Paris Descartes, F-75014 Paris, France
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The Laboratory of Lymphocyte Signaling and Oncoproteome, Department I of Internal Medicine, Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Duesseldorf, CECAD and CMMC, University of Cologne, 50937 Cologne, Germany
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Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45122 Essen, Germany
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Reference and Consultant Center for Lymph Node and Lymphoma diagnostics, 60590 Frankfurt, Germany
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Frankfurt Institute of Advanced Studies, 60438 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
Equally contributed.
Cancers 2019, 11(10), 1484; https://doi.org/10.3390/cancers11101484
Received: 22 August 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 2 October 2019
Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL. View Full-Text
Keywords: anaplastic large cell lymphoma; dissemination; rosetting T cells; classical Hodgkin lymphoma; chemokine receptors; cell motility; segmentation; image analysis; gene expression anaplastic large cell lymphoma; dissemination; rosetting T cells; classical Hodgkin lymphoma; chemokine receptors; cell motility; segmentation; image analysis; gene expression
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Goncharova, O.; Flinner, N.; Bein, J.; Döring, C.; Donnadieu, E.; Rikirsch, S.; Herling, M.; Küppers, R.; Hansmann, M.-L.; Hartmann, S. Migration Properties Distinguish Tumor Cells of Classical Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma Cells. Cancers 2019, 11, 1484.

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