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Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers

Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany
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Cancers 2019, 11(1), 24; https://doi.org/10.3390/cancers11010024
Received: 16 November 2018 / Revised: 20 December 2018 / Accepted: 21 December 2018 / Published: 27 December 2018
(This article belongs to the Special Issue Obesity as a Risk Factor for Cancer)
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Abstract

Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers. View Full-Text
Keywords: Obesity; low-grade inflammation; liver and colon cancer; IL-6 and TNF; signaling Obesity; low-grade inflammation; liver and colon cancer; IL-6 and TNF; signaling
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Kern, L.; Mittenbühler, M.J.; Vesting, A.J.; Ostermann, A.L.; Wunderlich, C.M.; Wunderlich, F.T. Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers. Cancers 2019, 11, 24.

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