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Cancers 2018, 10(9), 309; https://doi.org/10.3390/cancers10090309

A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers

1
Unit of Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milano, Italy
2
Department of Biomedical Sciences for Health, University of Milan, 20133 Milano, Italy
3
Unit of Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milano, Italy
4
Senology Research Center—1st Division of Surgery, Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy
5
Senology Research Center—ASST Spedali Civili di Brescia, 25123 Brescia, Italy
6
Genetic Counselling Service, Institute of Oncology of Southern Switzerland (IOSI), 6500 Bellinzona, Switzerland
7
Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milano, Italy
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 31 August 2018 / Accepted: 2 September 2018 / Published: 4 September 2018
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Abstract

Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the ‘Mediterranean diet’, with moderate protein restriction, on serum levels of IGF-I and IRm. Methods: BRCA mutation carriers, with or without breast cancer, aged 18–70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. Results: 213 BRCA mutation carriers completed the six-month study. Women in the intervention group (110) showed major changes in all the parameters under study. They significantly lost weight (p < 0.001), fat mass (p = 0.002), with reduced hip circumference (p = 0.01), triglycerides (p = 0.02) and IGF-I (p = 0.02) compared with controls. They also had a significantly higher levels of insulin-like growth factor-binding protein 3 (IGFI-BP3) (p = 0.03) and a lower IGF-I/IGFI-BP3 ratio (p = 0.04). The reduction of serum levels of IGF-I was significantly associated with the reduction in the consumption of animal products (p = 0.04). Conclusions: Women in the intervention group showed significant improvements in IGF-I and in other IRm that might influence the penetrance of BRCA mutations. View Full-Text
Keywords: BRCA genes; mutation carriers; IGF-I; diet; penetrance BRCA genes; mutation carriers; IGF-I; diet; penetrance
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Pasanisi, P.; Bruno, E.; Venturelli, E.; Morelli, D.; Oliverio, A.; Baldassari, I.; Rovera, F.; Iula, G.; Taborelli, M.; Peissel, B.; Azzollini, J.; Manoukian, S. A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers. Cancers 2018, 10, 309.

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