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Cancers 2018, 10(8), 247;

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
Institute of Cancer and Genomic Medicine, University of Birmingham, Birmingham B15 2TT, UK
Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 23 July 2018 / Accepted: 25 July 2018 / Published: 27 July 2018
(This article belongs to the Special Issue Epstein–Barr Virus Associated Cancers)
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The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed. View Full-Text
Keywords: TGF-β signalling; Epstein-Barr virus; nasopharyngeal carcinoma; gastric cancer; B-cell lymphoma TGF-β signalling; Epstein-Barr virus; nasopharyngeal carcinoma; gastric cancer; B-cell lymphoma

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Velapasamy, S.; Dawson, C.W.; Young, L.S.; Paterson, I.C.; Yap, L.F. The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers. Cancers 2018, 10, 247.

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