Next Article in Journal
Antiviral Drugs for EBV
Next Article in Special Issue
Dynamics of p14ARF and Focal Adhesion Kinase-Mediated Autophagy in Cancer
Previous Article in Journal
Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA
Open AccessReview

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development

King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Division of Biological and Environmental Sciences and Engineering (BESE), Thuwal 23955-6900, Saudi Arabia
*
Author to whom correspondence should be addressed.
Contributed equally.
Cancers 2018, 10(6), 196; https://doi.org/10.3390/cancers10060196
Received: 7 May 2018 / Revised: 31 May 2018 / Accepted: 6 June 2018 / Published: 11 June 2018
(This article belongs to the Special Issue FAK Signaling Pathway in Cancers)
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 have been found to have promising antitumor activity, their clinical long-term efficacy may be undermined by the strong capacity of cancer cells to evade anti-kinase drugs. In healthy cells, the expression and/or function of FAK and PYK2 is tightly controlled via modulation of gene expression, competing alternatively spliced forms, non-coding RNAs, and proteins that directly or indirectly affect kinase activation or protein stability. The molecular factors involved in this control are frequently deregulated in cancer cells. Here, we review the endogenous mechanisms controlling FAK and PYK2, and with particular focus on how these mechanisms could inspire or improve anticancer therapies. View Full-Text
Keywords: dimerization; miRNA; motility; anoikis; chaperon; PTEN; FIP200; LKB1; PI3K; regulation dimerization; miRNA; motility; anoikis; chaperon; PTEN; FIP200; LKB1; PI3K; regulation
Show Figures

Figure 1

MDPI and ACS Style

Naser, R.; Aldehaiman, A.; Díaz-Galicia, E.; Arold, S.T. Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development. Cancers 2018, 10, 196.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop