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mTOR Cross-Talk in Cancer and Potential for Combination Therapy
Open AccessEditorial

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting

1
School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
2
Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(6), 168; https://doi.org/10.3390/cancers10060168
Received: 23 May 2018 / Accepted: 24 May 2018 / Published: 30 May 2018
(This article belongs to the Special Issue mTOR Pathway in Cancer)
This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression. View Full-Text
Keywords: mTOR; cancer mTOR; cancer
MDPI and ACS Style

Murray, J.T.; Tee, A.R. Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting. Cancers 2018, 10, 168.

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