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Bladder Cancer: New Insights into Its Molecular Pathology

Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
Cancers 2018, 10(4), 100; https://doi.org/10.3390/cancers10040100
Received: 26 February 2018 / Revised: 27 March 2018 / Accepted: 28 March 2018 / Published: 1 April 2018
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Abstract

Bladder cancer is one of the most prevalent cancers worldwide. Unfortunately, there have been few advances in its clinical management due to a poor understanding of the correlations between its molecular and clinical features. Mounting evidence suggests that bladder cancer comprises a group of molecularly heterogeneous diseases that undergo a variety of clinical courses and possess diverse therapeutic responses. Owing to the close association between its molecular subtypes and clinicopathological features, specific therapeutic strategies have recently been suggested. This review summarizes the current understanding of the molecular pathology of bladder cancer, including its molecular biomarkers/pathways and molecular subtypes that have been newly identified using high-throughput technologies. It also discusses advances in our understanding of personalized treatments for specific molecular subtypes. View Full-Text
Keywords: APOBEC; FGFR3; GATA3; immune checkpoint inhibitor; molecular pathological epidemiology; PD-L1; precision medicine; The Cancer Genome Atlas (TCGA); uroplakin; urothelial carcinoma APOBEC; FGFR3; GATA3; immune checkpoint inhibitor; molecular pathological epidemiology; PD-L1; precision medicine; The Cancer Genome Atlas (TCGA); uroplakin; urothelial carcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Inamura, K. Bladder Cancer: New Insights into Its Molecular Pathology. Cancers 2018, 10, 100.

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