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Radiotherapy as a New Player in Immuno-Oncology

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA
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Author to whom correspondence should be addressed.
Cancers 2018, 10(12), 515; https://doi.org/10.3390/cancers10120515
Received: 7 November 2018 / Revised: 10 December 2018 / Accepted: 11 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue New Developments in Radiotherapy)
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy in cancer treatments. However, antitumor immune effects of radiotherapy are limited by the concomitant induction of radiation-dependent immunosuppressive effects. In the growing era of immunotherapy, combining radiotherapy with immunomodulating agents has demonstrated enhancement of radiation-induced antitumor immune activation that correlated with improved treatment outcomes. Yet, how to optimally deliver combination therapy regarding dose-fractionation and timing of radiotherapy is largely unknown. Future prospective testing to fine-tune this promising combination of radiotherapy and immunotherapy is warranted. View Full-Text
Keywords: radiotherapy; radiation; immunotherapy; combination therapy; cancer; dose-fractionation; timing radiotherapy; radiation; immunotherapy; combination therapy; cancer; dose-fractionation; timing
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Wang, S.-J.; Haffty, B. Radiotherapy as a New Player in Immuno-Oncology. Cancers 2018, 10, 515.

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