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BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression

by Xiaowen Zhang * and Rong Li *
Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037, USA
*
Authors to whom correspondence should be addressed.
Cancers 2018, 10(12), 513; https://doi.org/10.3390/cancers10120513
Received: 14 October 2018 / Revised: 24 November 2018 / Accepted: 11 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue BRCA Mutations and Cancer)
Germ-line mutations in breast cancer susceptibility gene 1 (BRCA1) predominantly predispose women to breast and ovarian cancers. BRCA1 is best known for its functions in maintenance of genomic integrity including repairing DNA double-strand breaks through homologous recombination and suppressing DNA replication stress. However, whether these universally important BRCA1 functions in maintenance of genomic stability are sufficient to account for its tissue-specific tumor-suppressing function remains unclear. Accumulating evidence indicates that there are previously underappreciated roles of BRCA1 in transcriptional regulation and chromatin remodeling. In this review, we discuss the functional significance of interactions between BRCA1 and various transcription factors, its role in epigenetic regulation and chromatin dynamics, and BRCA1-dependent crosstalk between the machineries of transcription and genome integrity. Furthermore, we propose a model of how transcriptional regulation could contribute to tissue-dependent tumor-suppressing function of BRCA1. View Full-Text
Keywords: BRCA1; transcriptional regulation; epigenetic regulation; chromatin organization BRCA1; transcriptional regulation; epigenetic regulation; chromatin organization
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Zhang, X.; Li, R. BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression. Cancers 2018, 10, 513.

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