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Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis

1
Aix Marseille Univ, INSERM 1263, INRA 1260, C2VN, Faculty of pharmacy, 27 Boulevard Jean Moulin, 13385 Marseille, France
2
Department of Digestive Surgery, Timone University Hospital, 13385 Marseille, France
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(11), 441; https://doi.org/10.3390/cancers10110441
Received: 30 September 2018 / Revised: 31 October 2018 / Accepted: 10 November 2018 / Published: 14 November 2018
(This article belongs to the Special Issue The Role of Thrombosis and Haemostasis in Cancer)
Platelets are small anucleate cells that are traditionally described as the major effectors of hemostasis and thrombosis. However, increasing evidence indicates that platelets play several roles in the progression of malignancies and in cancer-associated thrombosis. A notable cross-communication exists between platelets and cancer cells. On one hand, cancer can “educate” platelets, influencing their RNA profiles, the numbers of circulating platelets and their activation states. On the other hand, tumor-educated platelets contain a plethora of active biomolecules, including platelet-specific and circulating ingested biomolecules, that are released upon platelet activation and participate in the progression of malignancy. The numerous mechanisms by which the primary tumor induces the production, activation and aggregation of platelets (also known as tumor cell induced platelet aggregation, or TCIPA) are directly related to the pro-thrombotic state of cancer patients. Moreover, the activation of platelets is critical for tumor growth and successful metastatic outbreak. The development or use of existing drugs targeting the activation of platelets, adhesive proteins responsible for cancer cell-platelet interactions and platelet agonists should be used to reduce cancer-associated thrombosis and tumor progression. View Full-Text
Keywords: platelets; cancer cells; tumor cell induced platelet aggregation (TCIPA); tumor educated platelets (TEP); cancer-associated thrombosis platelets; cancer cells; tumor cell induced platelet aggregation (TCIPA); tumor educated platelets (TEP); cancer-associated thrombosis
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Plantureux, L.; Mège, D.; Crescence, L.; Dignat-George, F.; Dubois, C.; Panicot-Dubois, L. Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis. Cancers 2018, 10, 441.

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