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Cancers 2018, 10(1), 9; https://doi.org/10.3390/cancers10010009

Current Advances in Aptamers for Cancer Diagnosis and Therapy

1
Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA
2
Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan
3
Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA
The first two authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 December 2017 / Revised: 22 December 2017 / Accepted: 26 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Aptamers: Promising Tools for Cancer Diagnosis and Therapy)
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Abstract

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy. View Full-Text
Keywords: cell-specific aptamer; SELEX; cancer diagnosis; cancer therapy; targeted delivery cell-specific aptamer; SELEX; cancer diagnosis; cancer therapy; targeted delivery
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Hori, S.-I.; Herrera, A.; Rossi, J.J.; Zhou, J. Current Advances in Aptamers for Cancer Diagnosis and Therapy. Cancers 2018, 10, 9.

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