Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator

Li, Zihao; Zhu, Chenggang; Guo, Zhihe; Wang, Bowen; Wu, Xiang; Fei, Yiyan

doi:10.3390/mi9060274

Open AccessArticle

Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator

by

Zihao Li

^†,

Chenggang Zhu

^†,

Zhihe Guo

,

Bowen Wang

,

Xiang Wu

^* and

Yiyan Fei

^*

Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan University, Shanghai 200433, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Micromachines 2018, 9(6), 274; https://doi.org/10.3390/mi9060274

Submission received: 8 April 2018 / Revised: 20 May 2018 / Accepted: 29 May 2018 / Published: 31 May 2018

(This article belongs to the Special Issue Glassy Materials Based Microdevices)

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Abstract

The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.

Keywords: label-free sensor; optofluidic microbubble resonator; detection of small molecules

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MDPI and ACS Style

Li, Z.; Zhu, C.; Guo, Z.; Wang, B.; Wu, X.; Fei, Y. Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator. Micromachines 2018, 9, 274. https://doi.org/10.3390/mi9060274

AMA Style

Li Z, Zhu C, Guo Z, Wang B, Wu X, Fei Y. Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator. Micromachines. 2018; 9(6):274. https://doi.org/10.3390/mi9060274

Chicago/Turabian Style

Li, Zihao, Chenggang Zhu, Zhihe Guo, Bowen Wang, Xiang Wu, and Yiyan Fei. 2018. "Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator" Micromachines 9, no. 6: 274. https://doi.org/10.3390/mi9060274

APA Style

Li, Z., Zhu, C., Guo, Z., Wang, B., Wu, X., & Fei, Y. (2018). Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator. Micromachines, 9(6), 274. https://doi.org/10.3390/mi9060274

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Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator

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