Next Article in Journal
Technology for 3D System Integration for Flexible Wireless Biomedical Applications
Next Article in Special Issue
Design and Fabrication of a Microfluidic Viscometer Based on Electrofluidic Circuits
Previous Article in Journal
Novel EMD-Based Extraction Approach of Electric Field Fringe Impacts on a Micro Capacitive Displacement Sensor
Previous Article in Special Issue
Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection
Open AccessArticle

Fabricating and Characterizing the Microfluidic Solid Phase Extraction Module Coupling with Integrated ESI Emitters

by 1,‡, 1,‡, 1,*, 1 and 1,2
1
Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
The State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
This paper is an extended version of our paper presented in the 19th Annual Conference of the Chinese Society of Micro-Nano Technology, Dalian, China, 26–29 October 2017.
These authors contributed equally to this work.
This paper is an extended version of our paper presented in the 19th Annual Conference of the Chinese Society of Micro-Nano Technology, Dalian, China, 26–29 October 2017.
Micromachines 2018, 9(5), 212; https://doi.org/10.3390/mi9050212
Received: 5 March 2018 / Revised: 13 April 2018 / Accepted: 24 April 2018 / Published: 1 May 2018
(This article belongs to the Special Issue Microfluidic Sensors)
Microfluidic chips coupling with mass spectrometry (MS) will be of great significance to the development of relevant instruments involving chemical and bio-chemical analysis, drug detection, food and environmental applications and so on. In our previous works, we proposed two types of microfluidic electrospray ionization (ESI) chip coupling with MS: the two-phase flow focusing (FF) ESI microfluidic chip and the corner-integrated ESI emitter, respectively. However the pretreatment module integrated with these ESI emitters is still a challenging problem. In this paper, we concentrated on integrating the solid phase micro-extraction (SPME) module with our previous proposed on-chip ESI emitters; the fabrication processes of such SPME module are fully compatible with our previous proposed ESI emitters based on the multi-layer soft lithography. We optimized the structure of the integrated chip and characterized its performance using standard samples. Furthermore, we verified its abilities of salt removal, extraction of multiple analytes and separation through on-chip elution using mimic biological urine spiked with different drugs. The results indicated that our proposed integrated module with ESI emitters is practical and effective for real biological sample pretreatment and MS detection. View Full-Text
Keywords: microfluidic chip; solid phase extraction; mass spectrometry; two-phase flow focusing; integrated electrospray ionization (ESI) emitter; on-chip solid phase micro-extraction (SPME) module; pretreatment technology microfluidic chip; solid phase extraction; mass spectrometry; two-phase flow focusing; integrated electrospray ionization (ESI) emitter; on-chip solid phase micro-extraction (SPME) module; pretreatment technology
Show Figures

Figure 1

MDPI and ACS Style

Tang, H.; Yu, Q.; Qian, X.; Ni, K.; Wang, X. Fabricating and Characterizing the Microfluidic Solid Phase Extraction Module Coupling with Integrated ESI Emitters. Micromachines 2018, 9, 212.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop