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Micromachines 2017, 8(7), 210;

New Endoscopic Imaging Technology Based on MEMS Sensors and Actuators

Department of Radiology, Stanford University, Stanford, CA 94305, USA
Departments of Biomedical and Electronics Engineering, King Mongkut’s Institute of Technology Ladkrabang, Bangkok 10520, Thailand
Author to whom correspondence should be addressed.
Academic Editors: Shih-Chi Chen and Wei-Chuan Shih
Received: 31 December 2016 / Revised: 9 March 2017 / Accepted: 10 March 2017 / Published: 2 July 2017
(This article belongs to the Special Issue MEMS/NEMS for Biomedical Imaging and Sensing)
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Over the last decade, optical fiber-based forms of microscopy and endoscopy have extended the realm of applicability for many imaging modalities. Optical fiber-based imaging modalities permit the use of remote illumination sources and enable flexible forms supporting the creation of portable and hand-held imaging instrumentations to interrogate within hollow tissue cavities. A common challenge in the development of such devices is the design and integration of miniaturized optical and mechanical components. Until recently, microelectromechanical systems (MEMS) sensors and actuators have been playing a key role in shaping the miniaturization of these components. This is due to the precision mechanics of MEMS, microfabrication techniques, and optical functionality enabling a wide variety of movable and tunable mirrors, lenses, filters, and other optical structures. Many promising results from MEMS based optical fiber endoscopy have demonstrated great potentials for clinical translation. In this article, reviews of MEMS sensors and actuators for various fiber-optical endoscopy such as fluorescence, optical coherence tomography, confocal, photo-acoustic, and two-photon imaging modalities will be discussed. This advanced MEMS based optical fiber endoscopy can provide cellular and molecular features with deep tissue penetration enabling guided resections and early cancer assessment to better treatment outcomes. View Full-Text
Keywords: endoscopy; MEMS; microfabrication; acoustic; biomedical optical imaging; confocal; fluorescence; two-photon; photoacoustic endoscopy; MEMS; microfabrication; acoustic; biomedical optical imaging; confocal; fluorescence; two-photon; photoacoustic

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Qiu, Z.; Piyawattanamatha, W. New Endoscopic Imaging Technology Based on MEMS Sensors and Actuators. Micromachines 2017, 8, 210.

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