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Micromachines 2017, 8(10), 299;

Bio-Inspired Microdevices that Mimic the Human Vasculature

Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
Departments of Mechanical and Aerospace Engineering, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA
Author to whom correspondence should be addressed.
Received: 30 August 2017 / Revised: 25 September 2017 / Accepted: 26 September 2017 / Published: 7 October 2017
(This article belongs to the Special Issue Bio-Inspired Micro/Nano Devices and Systems)
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Blood vessels may be found throughout the entire body and their importance to human life is undeniable. This is evident in the fact that a malfunctioning blood vessel can result in mild symptoms such as shortness of breath or chest pain to more severe symptoms such as a heart attack or stroke, to even death in the severest of cases. Furthermore, there are a host of pathologies that have been linked to the human vasculature. As a result many researchers have attempted to unlock the mysteries of the vasculature by performing studies that duplicate the physiological structural, chemical, and mechanical properties known to exist. While the ideal study would consist of utilizing living, blood vessels derived from human tissue, such studies are not always possible since intact human blood vessels are not readily accessible and there are immense technical difficulties associated with such studies. These limitations have opened the door for the development of microdevices modeled after the human vasculature as it is believed by many researchers in the field that such devices can one day replace tissue models. In this review we present an overview of microdevices developed to mimic various types of vasculature found throughout the human body. Although the human body contains a diverse array of vascular systems for this review we limit our discussion to the cardiovascular system and cerebrovascular system and discuss such systems that have been fabricated in both 2D and 3D configurations. View Full-Text
Keywords: endothelial cells; fluid shear stress; stretch; hydrogel; mechanical force; (polydimethylsiloxane) PDMS; blood vessels; blood brain barrier endothelial cells; fluid shear stress; stretch; hydrogel; mechanical force; (polydimethylsiloxane) PDMS; blood vessels; blood brain barrier

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Islam, M.M.; Beverung, S.; Steward Jr., R. Bio-Inspired Microdevices that Mimic the Human Vasculature. Micromachines 2017, 8, 299.

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