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Micromachines 2017, 8(10), 290;

Acoustic Manipulation of Bio-Particles at High Frequencies: An Analytical and Simulation Approach

School of Mechanical Engineering, College of Engineering, University of Tehran, North Kargar St., Tehran 14395-515, Iran
Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
Center for Bioengineering Research and Education, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada
Authors to whom correspondence should be addressed.
Received: 21 August 2017 / Revised: 16 September 2017 / Accepted: 21 September 2017 / Published: 27 September 2017
(This article belongs to the Special Issue Acoustofluidics in Medicine and Biology)
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Manipulation of micro and nano particles in microfluidic devices with high resolution is a challenge especially in bioengineering applications where bio-particles (BPs) are separated or patterned. While acoustic forces have been used to control the position of BPs, its theoretical aspects need further investigation particularly for high-resolution manipulation where the wavelength and particle size are comparable. In this study, we used a finite element method (FEM) to amend analytical calculations of acoustic radiation force (ARF) arising from an imposed standing ultrasound field. First, an acoustic solid interaction (ASI) approach was implemented to calculate the ARF exerted on BPs and resultant deformation induced to them. The results were then used to derive a revised expression for the ARF beyond the small particle assumption. The expression was further assessed in numerical simulations of one- and multi-directional standing acoustic waves (SAWs). Furthermore, a particle tracing scheme was used to investigate the effect of actual ARF on separation and patterning applications under experimentally-relevant conditions. The results demonstrated a significant mismatch between the actual force and previous analytical predictions especially for high frequencies of manipulation. This deviation found to be not only because of the shifted ARF values but also due to the variation in force maps in multidirectional wave propagation. Findings of this work can tackle the simulation limitations for spatiotemporal control of BPs using a high resolution acoustic actuation. View Full-Text
Keywords: acoustic radiation force (ARF); standing acoustic waves (SAW); bio-particle; microfluidics acoustic radiation force (ARF); standing acoustic waves (SAW); bio-particle; microfluidics

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Samandari, M.; Abrinia, K.; Sanati-Nezhad, A. Acoustic Manipulation of Bio-Particles at High Frequencies: An Analytical and Simulation Approach. Micromachines 2017, 8, 290.

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