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Micromachines 2016, 7(8), 135;

An Implantable Intravascular Pressure Sensor for a Ventricular Assist Device

Department of Electrical Engineering, ESAT-MICAS, KU Leuven, Kasteelpark Arenberg 10, 3001 Heverlee, Belgium
Department of Cardiovascular Sciences, Experimental Cardiac Surgery, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Kenichi Takahata
Received: 16 June 2016 / Revised: 4 July 2016 / Accepted: 29 July 2016 / Published: 8 August 2016
(This article belongs to the Special Issue Implantable Microsystems)
PDF [7744 KB, uploaded 8 August 2016]


The aim of this study is to investigate the intravascular application of a micro-electro-mechanical system (MEMS) pressure sensor to directly measure the hemodynamic characteristics of a ventricular assist device (VAD). A bio- and hemo-compatible packaging strategy is implemented, based on a ceramic thick film process. A commercial sub-millimeter piezoresistive sensor is attached to an alumina substrate, and a double coating of polydimethylsiloxane (PDMS) and parylene-C is applied. The final size of the packaged device is 2.6 mm by 3.6 mm by 1.8 mm. A prototype electronic circuit for conditioning and read-out of the pressure signal is developed, satisfying the VAD-specific requirements of low power consumption (less than 14.5 mW in continuous mode) and small form factor. The packaged sensor has been submitted to extensive in vitro tests. The device displayed a temperature-independent sensitivity (12 μ V/V/mmHg) and good in vitro stability when exposed to the continuous flow of saline solution (less than 0.05 mmHg/day drift after 50 h). During in vivo validation, the transducer has been successfully used to record the arterial pressure waveform of a female sheep. A small, intravascular sensor to continuously register the blood pressure at the inflow and the outflow of a VAD is developed and successfully validated in vivo. View Full-Text
Keywords: pressure sensor; MEMS; parylene; hemocompatibility; packaging; VAD pressure sensor; MEMS; parylene; hemocompatibility; packaging; VAD

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Brancato, L.; Keulemans, G.; Verbelen, T.; Meyns, B.; Puers, R. An Implantable Intravascular Pressure Sensor for a Ventricular Assist Device. Micromachines 2016, 7, 135.

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