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Micromachines 2016, 7(4), 70;

Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review

School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
ArtIC Photonics, 260 Terence Matthews Cres, Ottawa, ON K2M 2C7, Canada
Information and Communication Technologies, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada
Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
Author to whom correspondence should be addressed.
Academic Editors: Shih-Kang Fan and Nam-Trung Nguyen
Received: 1 March 2016 / Revised: 4 April 2016 / Accepted: 12 April 2016 / Published: 15 April 2016
(This article belongs to the Special Issue Optofluidics 2015)
Full-Text   |   PDF [2733 KB, uploaded 15 April 2016]   |  


Optofluidic devices combining micro-optical and microfluidic components bring a host of new advantages to conventional microfluidic devices. Aspects, such as optical beam shaping, can be integrated on-chip and provide high-sensitivity and built-in optical alignment. Optofluidic microflow cytometers have been demonstrated in applications, such as point-of-care diagnostics, cellular immunophenotyping, rare cell analysis, genomics and analytical chemistry. Flow control, light guiding and collecting, data collection and data analysis are the four main techniques attributed to the performance of the optofluidic microflow cytometer. Each of the four areas is discussed in detail to show the basic principles and recent developments. 3D microfabrication techniques are discussed in their use to make these novel microfluidic devices, and the integration of the whole system takes advantage of the miniaturization of each sub-system. The combination of these different techniques is a spur to the development of microflow cytometers, and results show the performance of many types of microflow cytometers developed recently. View Full-Text
Keywords: optofluidic device; microfluidics; microflow cytometer; microfabrication optofluidic device; microfluidics; microflow cytometer; microfabrication

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Zhang, Y.; Watts, B.R.; Guo, T.; Zhang, Z.; Xu, C.; Fang, Q. Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review. Micromachines 2016, 7, 70.

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