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A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array

Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, China
Authors to whom correspondence should be addressed.
Micromachines 2012, 3(2), 279-294;
Received: 11 February 2012 / Revised: 15 March 2012 / Accepted: 27 March 2012 / Published: 29 March 2012
(This article belongs to the Special Issue Micro Flow Controllers)
This paper presents an integrated digitally controllable microfluidic system for continuous solution supply with a real-time concentration control. This system contains multiple independently operating mixing modules, each integrated with two vortex micropumps, two Tesla valves and a micromixer. The interior surface of the system is made of biocompatible materials using a polymer micro-fabrication process and thus its operation can be applied to chemicals and bio-reagents. In each module, pumping of fluid is achieved by the vortex micropump working with the rotation of a micro-impeller. The downstream fluid mixing is based on mechanical vibrations driven by a lead zirconate titanate ceramic diaphragm actuator located below the mixing chamber. We have conducted experiments to prove that the addition of the micro-pillar structures to the mixing chamber further improves the mixing performance. We also developed a computer-controlled automated driver system to control the real-time fluid mixing and concentration regulation with the mixing module array. This research demonstrates the integration of digitally controllable polymer-based microfluidic modules as a fully functional system, which has great potential in the automation of many bio-fluid handling processes in bio-related applications. View Full-Text
Keywords: microfluidic; pump; mix; tesla; valve; integration microfluidic; pump; mix; tesla; valve; integration
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MDPI and ACS Style

Lam, R.H.W.; Li, W.J. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines 2012, 3, 279-294.

AMA Style

Lam RHW, Li WJ. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines. 2012; 3(2):279-294.

Chicago/Turabian Style

Lam, Raymond H. W., and Wen J. Li 2012. "A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array" Micromachines 3, no. 2: 279-294.

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