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Editorial for the Special Issue on Micromachines for Dielectrophoresis, Volume II
 
 
Article
Peer-Review Record

Pollution-Free and Highly Sensitive Lactate Detection in Cell Culture Based on a Microfluidic Chip

Micromachines 2023, 14(4), 770; https://doi.org/10.3390/mi14040770
by Jiaming Shi 1, Wenqiang Tong 1, Zhihang Yu 1, Lei Tong 1, Huaying Chen 2, Jing Jin 2 and Yonggang Zhu 1,2,*
Reviewer 2: Anonymous
Micromachines 2023, 14(4), 770; https://doi.org/10.3390/mi14040770
Submission received: 1 March 2023 / Revised: 23 March 2023 / Accepted: 26 March 2023 / Published: 30 March 2023

Round 1

Reviewer 1 Report

This manuscript presents a microfluidic chip composed of a backflow prevention channel, which is used for cell culture and lactate detection. This chip has good stability in metabolite quick monitoring. However, this manuscript requires revisions majors based on the following topics:

1.-The introduction should include the main limitations of the microfluidic devices for cell culture and lactate detection. 

2.-What are the main advantages of the proposed microfluidic chip?

3.- The description of the 3D model should incorporate the main assumptions, boundary and load conditions, mesh, and analysis type.

4.-The resolution of Figures 3 (A-C), 4, 5, 6, 7, 8, 9, 10, and 11 must be significantly improved. 

5.- The discussions of the main results shown in Figures 6, 8, 10, and 11 should be enhanced.

6.-What are the main limitations of the proposed microfluidic chip?

7.- What is the future research work?

 

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

please see attached

Comments for author File: Comments.docx

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors improved their manuscript based on the reviewer's comments. 

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