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Article

Angiogenesis and Functional Vessel Formation Induced by Interstitial Flow and Vascular Endothelial Growth Factor Using a Microfluidic Chip

1
Department of Oral Pathology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Tianjin Road No. 2, Huangpu District, Shanghai 200001, China
2
Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Tianjin Road No. 2, Huangpu District, Shanghai 200001, China
3
School of Stomatology, Dalian Medical University, West Section No. 9, Sourth Road of Lvshun, Dalian 116044, China
4
Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Zhongshan Road No. 456, Dalian 116023, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Ludovica Cacopardo, Sandeep Keshavan and Bharath Babu Nunna
Micromachines 2022, 13(2), 225; https://doi.org/10.3390/mi13020225
Received: 13 January 2022 / Revised: 26 January 2022 / Accepted: 27 January 2022 / Published: 29 January 2022
Angiogenesis occurs during both physiological and pathological processes. In this study, a microfluidic chip for the development of angiogenesis was utilized to assess angiogenic sprouting and functional vessel formation. We also found that vascular endothelial growth factor (VEGF) was a determinant of the initiation of vascular sprouts, while the direction of these sprouts was greatly influenced by interstitial flow. Isoforms of VEGF such as VEGF121, VEGF165, and VEGF189 displayed different angiogenic properties on the chip as assessed by sprout length and number, vessel perfusion, and connectivity. VEGF165 had the highest capacity to induce vascular sprouting among the three isoforms assessed and furthermore, also induced functional vessel formation. This chip could be used to analyze the effect of different angiogenic factors and drugs, as well as to explore the mechanism of angiogenesis induced by such factors. View Full-Text
Keywords: angiogenesis; interstitial flow; VEGF; microfluidic angiogenesis; interstitial flow; VEGF; microfluidic
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MDPI and ACS Style

Liu, Y.; Li, J.; Zhou, J.; Liu, X.; Li, H.; Lu, Y.; Lin, B.; Li, X.; Liu, T. Angiogenesis and Functional Vessel Formation Induced by Interstitial Flow and Vascular Endothelial Growth Factor Using a Microfluidic Chip. Micromachines 2022, 13, 225. https://doi.org/10.3390/mi13020225

AMA Style

Liu Y, Li J, Zhou J, Liu X, Li H, Lu Y, Lin B, Li X, Liu T. Angiogenesis and Functional Vessel Formation Induced by Interstitial Flow and Vascular Endothelial Growth Factor Using a Microfluidic Chip. Micromachines. 2022; 13(2):225. https://doi.org/10.3390/mi13020225

Chicago/Turabian Style

Liu, Yufang, Jiao Li, Jiasheng Zhou, Xue Liu, Huibing Li, Yao Lu, Bingcheng Lin, Xiaojie Li, and Tingjiao Liu. 2022. "Angiogenesis and Functional Vessel Formation Induced by Interstitial Flow and Vascular Endothelial Growth Factor Using a Microfluidic Chip" Micromachines 13, no. 2: 225. https://doi.org/10.3390/mi13020225

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