Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel

Sharif, Saqib; Nguyen, Kim Tien; Bang, Doyeon; Park, Jong-Oh; Choi, Eunpyo

doi:10.3390/mi12040424

Open AccessArticle

Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel

by

Saqib Sharif

^1,2,

Kim Tien Nguyen

^1,2

,

Doyeon Bang

^2,3,

Jong-Oh Park

^1,2,* and

Eunpyo Choi

^1,2,*

¹

School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea

²

Korea Institute of Medical Microrobotics, Gwangju 61011, Korea

³

College of AI Convergence, Chonnam National University, Gwangju 61186, Korea

^*

Authors to whom correspondence should be addressed.

Micromachines 2021, 12(4), 424; https://doi.org/10.3390/mi12040424

Submission received: 4 February 2021 / Revised: 8 April 2021 / Accepted: 8 April 2021 / Published: 13 April 2021

(This article belongs to the Special Issue Micro/Nanorobotics)

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Abstract

Microscale and nanoscale robots, frequently referred to as future cargo systems for targeted drug delivery, can effectively convert magnetic energy into locomotion. However, navigating and imaging them within a complex colloidal vascular system at a clinical scale is exigent. Hence, a more precise and enhanced hybrid control navigation and imaging system is necessary. Magnetic particle imaging (MPI) has been successfully applied to visualize the ensemble of superparamagnetic nanoparticles (MNPs) with high temporal sensitivity. MPI uses the concept of field-free point (FFP) mechanism in the principal magnetic field. The gradient magnetic field (|∇B|) of MPI scanners can generate sufficient magnetic force in MNPs; hence, it has been recently used to navigate nanosized particles and micron-sized swimmers. In this article, we present a simulation analysis of the optimized navigation of an ensemble of microsized polymer MNP-based drug carriers in blood vessels. Initially, an ideal two-dimensional FFP case is employed for the basic optimization of the FFP position to achieve efficient navigation. Thereafter, a nine-coil electromagnetic actuation simulation system is developed to generate and manipulate the FFP position and |∇B|. Under certain vessel and fluid conditions, the particle trajectories of different ferromagnetic polymer ratios and |∇B| were compared to optimize the FFP position.

Keywords: microrobots; field-free point; magnetic nanoparticle; 3D localization

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MDPI and ACS Style

Sharif, S.; Nguyen, K.T.; Bang, D.; Park, J.-O.; Choi, E. Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel. Micromachines 2021, 12, 424. https://doi.org/10.3390/mi12040424

AMA Style

Sharif S, Nguyen KT, Bang D, Park J-O, Choi E. Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel. Micromachines. 2021; 12(4):424. https://doi.org/10.3390/mi12040424

Chicago/Turabian Style

Sharif, Saqib, Kim Tien Nguyen, Doyeon Bang, Jong-Oh Park, and Eunpyo Choi. 2021. "Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel" Micromachines 12, no. 4: 424. https://doi.org/10.3390/mi12040424

APA Style

Sharif, S., Nguyen, K. T., Bang, D., Park, J.-O., & Choi, E. (2021). Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel. Micromachines, 12(4), 424. https://doi.org/10.3390/mi12040424

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel

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