Next Article in Journal
Scalable Parallel Manipulation of Single Cells Using Micronozzle Array Integrated with Bidirectional Electrokinetic Pumps
Previous Article in Journal
High-Throughput Particle Concentration Using Complex Cross-Section Microchannels
micromachines-logo
Article Menu
Open AccessArticle

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

1
Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Valle de las Palmas, Mexico. Blvd. Universitario #1000, Unidad Valle de las Palmas, 22260 Tijuana, Baja California, Mexico
2
National Collection of Industrial Microorganisms (NCIM), CSIR-National Chemical Laboratory, Pune-411008, Maharashtra, India
3
Universidad Nacional Autónoma de México, Centro de Nanociencias y Nanotecnología, Km. 107, Carretera Tijuana a Ensenada, C.P. 22860 Ensenada, Baja California, Mexico
4
“Complex Polymer Systems” Laboratory, Institut de Chimie et des Matériaux Paris-Est, Université Paris-Est Créteil, UMR 7182 CNRS, 2, rue Henri Dunant, F-94320 Thiais, France
5
Department of Technology of Organic Substances and Polymer Materials, Tomsk Polytechnic University, 634050 Tomsk, Russia
6
Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California- Campus Valle Dorado, Carretera Transpeninsular S/N, Valle Dorado, 22890 Ensenada, Baja California, Mexico
7
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, 21500 Tijuana, Baja California, Mexico
8
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630060 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(4), 441; https://doi.org/10.3390/mi11040441
Received: 13 February 2020 / Revised: 14 April 2020 / Accepted: 16 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Micro- and Nano-Fabrication of Polymers for Regenerative Medicine)
Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.
View Full-Text
Keywords: electrospinning; poly (ε-caprolactone); poly (vinyl pyrrolidone); silver sorbents; wound dressings electrospinning; poly (ε-caprolactone); poly (vinyl pyrrolidone); silver sorbents; wound dressings
Show Figures

Graphical abstract

MDPI and ACS Style

Álvarez-Suárez, A.S.; Dastager, S.G.; Bogdanchikova, N.; Grande, D.; Pestryakov, A.; García-Ramos, J.C.; Pérez-González, G.L.; Juárez-Moreno, K.; Toledano-Magaña, Y.; Smolentseva, E.; Paz-González, J.A.; Popova, T.; Rachkovskaya, L.; Nimaev, V.; Kotlyarova, A.; Korolev, M.; Letyagin, A.; Villarreal-Gómez, L.J. Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings. Micromachines 2020, 11, 441.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop