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High-Throughput Particle Concentration Using Complex Cross-Section Microchannels

Complex Systems Laboratory, School of Physics-Chemistry, Department of Physics, Alzahra University, Tehran 1993893973, Iran
School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
School of Paramedicine, Ilam University of Medical Science, Ilam 6939177143, Iran
School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia
Institute of Molecular Medicine, Sechenov University, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Micromachines 2020, 11(4), 440;
Received: 24 March 2020 / Revised: 17 April 2020 / Accepted: 20 April 2020 / Published: 22 April 2020
High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or CFN, which is indicative of the enhancement of inertial focusing of particles in these channels. Three spiral microchannels with various widths of 400 µm, 500 µm, and 600 µm, with the corresponding CFNs of 4.3, 4.5, and 6, respectively, were used. The device with the total width of 600 µm was shown to have a separation efficiency of ~98%, and by recirculating, the output concentration of the sample was 500 times higher than the initial input. Finally, the investigation of results showed that the magnitude of CFN relies entirely on the microchannel geometry, and it is independent of the overall width of the channel cross-section. We envision that this concept of particle focusing through complex cross-sections will prove useful in paving the way towards more efficient inertial microfluidic devices. View Full-Text
Keywords: Inertial microfluidics; complex cross-section; particle/cell concentrator Inertial microfluidics; complex cross-section; particle/cell concentrator
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MDPI and ACS Style

Mihandoust, A.; Razavi Bazaz, S.; Maleki-Jirsaraei, N.; Alizadeh, M.; A. Taylor, R.; Ebrahimi Warkiani, M. High-Throughput Particle Concentration Using Complex Cross-Section Microchannels. Micromachines 2020, 11, 440.

AMA Style

Mihandoust A, Razavi Bazaz S, Maleki-Jirsaraei N, Alizadeh M, A. Taylor R, Ebrahimi Warkiani M. High-Throughput Particle Concentration Using Complex Cross-Section Microchannels. Micromachines. 2020; 11(4):440.

Chicago/Turabian Style

Mihandoust, Asma, Sajad Razavi Bazaz, Nahid Maleki-Jirsaraei, Majid Alizadeh, Robert A. Taylor, and Majid Ebrahimi Warkiani. 2020. "High-Throughput Particle Concentration Using Complex Cross-Section Microchannels" Micromachines 11, no. 4: 440.

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