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Article

2D Spatially-Resolved Depth-Section Microfluidic Flow Velocimetry Using Dual Beam OCT

Centre for Engineering Photonics, Cranfield University, Cranfield MK43 0AL, Bedfordshire, UK
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Author to whom correspondence should be addressed.
Micromachines 2020, 11(4), 351; https://doi.org/10.3390/mi11040351
Received: 6 January 2020 / Revised: 19 March 2020 / Accepted: 24 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue MFHS 2019)
A dual beam optical coherence tomography (OCT) instrument has been developed for flow measurement that offers advantages over microscope derived imaging techniques. It requires only a single optical access port, allows simultaneous imaging of the microfluidic channel, does not require fluorescent seed particles, and can provide a millimetre-deep depth-section velocity profile (as opposed to horizontal-section). The dual beam instrument performs rapid re-sampling of particle positions, allowing measurement of faster flows. In this paper, we develop the methods and processes necessary to make 2D quantitative measurements of the flow-velocity using dual beam OCT and present exemplar results in a microfluidic chip. A 2D reference measurement of the Poiseuille flow in a microfluidic channel is presented over a spanwise depth range of 700 μm and streamwise length of 1600 μm with a spatial resolution of 10 μm, at velocities up to 50 mm/s. A measurement of a more complex flow field is also demonstrated in a sloped microfluidic section. View Full-Text
Keywords: optical coherence tomography (OCT); interferometry; microfluidics; flow measurement; particle image velocimetry (PIV) optical coherence tomography (OCT); interferometry; microfluidics; flow measurement; particle image velocimetry (PIV)
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    Doi: 10.17862/cranfield.rd.11522517
    Link: https://cord.cranfield.ac.uk/account/articles/11522517
    Description: The following are available at the Cranfield Online Data Repository (CORD):263 10.17862/cranfield.rd.11522517 : Video S1: Straight microfluidic chip section flow. Video S2: Sloped microfluidic264 chip section flow. Data and analysis code used to generate Figures.
MDPI and ACS Style

Hallam, J.M.; Rigas, E.; Charrett, T.O.H.; Tatam, R.P. 2D Spatially-Resolved Depth-Section Microfluidic Flow Velocimetry Using Dual Beam OCT. Micromachines 2020, 11, 351. https://doi.org/10.3390/mi11040351

AMA Style

Hallam JM, Rigas E, Charrett TOH, Tatam RP. 2D Spatially-Resolved Depth-Section Microfluidic Flow Velocimetry Using Dual Beam OCT. Micromachines. 2020; 11(4):351. https://doi.org/10.3390/mi11040351

Chicago/Turabian Style

Hallam, Jonathan M., Evangelos Rigas, Thomas O.H. Charrett, and Ralph P. Tatam 2020. "2D Spatially-Resolved Depth-Section Microfluidic Flow Velocimetry Using Dual Beam OCT" Micromachines 11, no. 4: 351. https://doi.org/10.3390/mi11040351

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