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Open AccessArticle

Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications

1
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
2
Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Prague 14220, Czech Republic
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(2), 158; https://doi.org/10.3390/mi11020158
Received: 13 December 2019 / Revised: 25 January 2020 / Accepted: 27 January 2020 / Published: 1 February 2020
Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration. View Full-Text
Keywords: chronic wounds; angiogenesis; antibacterial properties; drug delivery; microfluidics; nanoparticles; microparticles chronic wounds; angiogenesis; antibacterial properties; drug delivery; microfluidics; nanoparticles; microparticles
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Zarubova, J.; Hasani-Sadrabadi, M.M.; Bacakova, L.; Li, S. Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications. Micromachines 2020, 11, 158.

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