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Vascularized Microfluidics and the Blood–Endothelium Interface
Open AccessArticle

3D Sugar Printing of Networks Mimicking the Vasculature

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Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands
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Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands
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Polymer Technology, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands
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Author to whom correspondence should be addressed.
Micromachines 2020, 11(1), 43; https://doi.org/10.3390/mi11010043
Received: 15 November 2019 / Revised: 20 December 2019 / Accepted: 27 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Blood-on-a-Chip)
The vasculature plays a central role as the highway of the body, through which nutrients and oxygen as well as biochemical factors and signals are distributed by blood flow. Therefore, understanding the flow and distribution of particles inside the vasculature is valuable both in healthy and disease-associated networks. By creating models that mimic the microvasculature fundamental knowledge can be obtained about these parameters. However, microfabrication of such models remains a challenging goal. In this paper we demonstrate a promising 3D sugar printing method that is capable of recapitulating the vascular network geometry with a vessel diameter range of 1 mm down to 150 µm. For this work a dedicated 3D printing setup was built that is capable of accurately printing the sugar glass material with control over fibre diameter and shape. By casting of printed sugar glass networks in PDMS and dissolving the sugar glass, perfusable networks with circular cross-sectional channels are obtained. Using particle image velocimetry, analysis of the flow behaviour was conducted showing a Poisseuille flow profile inside the network and validating the quality of the printing process. View Full-Text
Keywords: 3D printing; sugar glass; microfluidics; microfabrication; microvasculature; flow analysis 3D printing; sugar glass; microfluidics; microfabrication; microvasculature; flow analysis
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MDPI and ACS Style

Pollet, A.M.A.O.; Homburg, E.F.G.A.; Cardinaels, R.; den Toonder, J.M.J. 3D Sugar Printing of Networks Mimicking the Vasculature. Micromachines 2020, 11, 43.

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