Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From Fabrication to Applications
by
Susana O. Catarino 1,†, Raquel O. Rodrigues 1,†, Diana Pinho 2,3,†,‡
, João M. Miranda 3, Graça Minas 1 and Rui Lima 3,4,*
, João M. Miranda 3, Graça Minas 1 and Rui Lima 3,4,*
1
Center for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
2
Research Centre in Digitalization and Intelligent Robotics (CeDRI), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
3
CEFT, Faculdade de Engenharia da Universidade do Porto (FEUP), Rua Roberto Frias, 4200-465 Porto, Portugal
4
MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Current affiliation: INL – International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal.
Micromachines 2019, 10(9), 593; https://doi.org/10.3390/mi10090593
Received: 2 August 2019 / Revised: 3 September 2019 / Accepted: 6 September 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Micro/Nano Devices for Blood Analysis)
Since the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, changes on blood cell physicochemical properties can be used for fast and accurate clinical diagnosis. In this review, an overview of the microfabrication techniques is given, especially for biomedical applications, as well as a synopsis of some design considerations regarding microfluidic devices. The blood cells separation and sorting techniques were also reviewed, highlighting the main achievements and breakthroughs in the last decades.
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Keywords:
microfluidics; red blood cells (RBCs); microfabrication; polymers; separation and sorting techniques
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Catarino, S.O.; Rodrigues, R.O.; Pinho, D.; Miranda, J.M.; Minas, G.; Lima, R. Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From Fabrication to Applications. Micromachines 2019, 10, 593.
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