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Open AccessFeature PaperCommunication

A Toolbox for Organelle Mechanobiology Research—Current Needs and Challenges

1
Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland
2
Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland
3
Scientific Center for Optical and Electron Microscopy (ScopeM), ETH Zurich, 8093 Zurich, Switzerland
4
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
*
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(8), 538; https://doi.org/10.3390/mi10080538
Received: 19 July 2019 / Revised: 4 August 2019 / Accepted: 9 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Microfluidics for Soft Matter and Mechanobiology)
Mechanobiology studies from the last decades have brought significant insights into many domains of biological research, from development to cellular signaling. However, mechano-regulation of subcellular components, especially membranous organelles, are only beginning to be unraveled. In this paper, we take mitochondrial mechanobiology as an example to discuss recent advances and current technical challenges in this field. In addition, we discuss the needs for future toolbox development for mechanobiological research of intracellular organelles. View Full-Text
Keywords: mechanobiology; mitochondria; organelles; microparticles; microfluidics; BioOptics; live-cell imaging mechanobiology; mitochondria; organelles; microparticles; microfluidics; BioOptics; live-cell imaging
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MDPI and ACS Style

Feng, Q.; Lee, S.S.; Kornmann, B. A Toolbox for Organelle Mechanobiology Research—Current Needs and Challenges. Micromachines 2019, 10, 538.

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