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Open AccessArticle

Connecting Mechanism for Artificial Blood Vessels with High Biocompatibility

Department of Mechanical Engineering, Keio university, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
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Micromachines 2019, 10(7), 429; https://doi.org/10.3390/mi10070429
Received: 27 May 2019 / Revised: 23 June 2019 / Accepted: 25 June 2019 / Published: 28 June 2019
This paper proposes a connecting mechanism for artificial vessels, which can be attached/detached with ease and does not deteriorate the biocompatibility of the vessels at the joint. The inner surface of the artificial vessels is designed to have high biocompatibility. In order to make the best of the property, the proposed connecting mechanism contacts and fixes the two artificial vessels whose contacting edges are turned inside out. In this manner, blood flowing inside the vessels only has contact with the biocompatible surface. The biocompatibility, or biofouling at the joint was investigated after in vitro blood circulation tests for 72 h with scanning electron microscopy. Blood coagulation for a short term (120 min) was evaluated by activated partial thromboplastin time (APTT). A decrease of APTT was observed, although it was too small to conclude that the connector augmented the blood coagulation. The micro dialysis device which our group has developed as the artificial kidney was inserted into the blood circulation system with the connector. Decrease of APTT was similarly small. These experiments verified that the proposed connector can be readily applicable for implantable medical devices. View Full-Text
Keywords: connector; artificial blood vessel; medical device; blood coagulation; implant; artificial kidney; biocompatible connector; artificial blood vessel; medical device; blood coagulation; implant; artificial kidney; biocompatible
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Watanabe, A.; Miki, N. Connecting Mechanism for Artificial Blood Vessels with High Biocompatibility. Micromachines 2019, 10, 429.

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