Development of the Troponin Detection System Based on the Nanostructure
by
Taek Lee 1,*, Jae-Hyuk Ahn 2, Jinha Choi 3, Yeonju Lee 1, Jin-Myung Kim 1, Chulhwan Park 1, Hongje Jang 4, Tae-Hyung Kim 5 and Min-Ho Lee 5,*
Taek Lee 1,*, Jae-Hyuk Ahn 2, Jinha Choi 3, Yeonju Lee 1, Jin-Myung Kim 1, Chulhwan Park 1, Hongje Jang 4, Tae-Hyung Kim 5 and Min-Ho Lee 5,*
1
Department of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea
2
Department of Electronic Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea
3
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 04107, Korea
4
Department of Chemistry, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea
5
School of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06974, Korea
*
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(3), 203; https://doi.org/10.3390/mi10030203
Received: 19 February 2019 / Revised: 17 March 2019 / Accepted: 17 March 2019 / Published: 22 March 2019
(This article belongs to the Special Issue Miniature Soft Biomedical Devices)
During the last 30 years, the World Health Organization (WHO) reported a gradual increase in the number of patients with cardiovascular disease (CVD), not only in developed but also in developing countries. In particular, acute myocardial infarction (AMI) is one of the severe CVDs because of the high death rate, damage to the body, and various complications. During these harmful effects, rapid diagnosis of AMI is key for saving patients with CVD in an emergency. The prompt diagnosis and proper treatment of patients with AMI are important to increase the survival rate of these patients. To treat patients with AMI quickly, detection of a CVD biomarker at an ultra-low concentration is essential. Cardiac troponins (cTNs), cardiac myoglobin (cMB), and creatine kinase MB are typical biomarkers for AMI detection. An increase in the levels of those biomarkers in blood implies damage to cardiomyocytes and thus is related to AMI progression. In particular, cTNs are regarded as a gold standard biomarker for AMI diagnosis. The conventional TN detection system for detection of AMI requires long measurement time and is labor-intensive and tedious. Therefore, the demand for sensitive and selective TN detection techniques is increasing at present. To meet this demand, several approaches and methods have been applied to develop a TN detection system based on a nanostructure. In the present review, the authors reviewed recent advances in TN biosensors with a focus on four detection systems: (1) An electrochemical (EC) TN nanobiosensor, (2) field effect transistor (FET)-based TN nanobiosensor, (3) surface plasmon resonance (SPR)-based TN nanobiosensor and (4) surface enhanced Raman spectroscopy (SERS)-based TN nanobiosensor.
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Keywords:
cardiac troponin detection system; acute myocardial infarction; electrochemical; field effect transistor; surface plasmon resonance; surface enhanced Raman spectroscopy; nanostructure
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MDPI and ACS Style
Lee, T.; Ahn, J.-H.; Choi, J.; Lee, Y.; Kim, J.-M.; Park, C.; Jang, H.; Kim, T.-H.; Lee, M.-H. Development of the Troponin Detection System Based on the Nanostructure. Micromachines 2019, 10, 203.
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